A presentation by Purdue University researchers, Dr. D. James and Dr. Dorothy M. Morré at the American Cell Biology Conference outlined the discovery, identification and investigation of the tumor-associated protein tNOX which is the molecular target for CAPSOL-T®. This discovery is an important advancement in understanding how cancer cells are able to grow and divide unchecked. tNOX is uniquely associated with all forms of cancer but is absent from normal cells.
The overactive tumor-associated tNOX protein is expressed exclusively by cancer cells and is blocked by quinone site inhibitors. CAPSOL-T® is formulated with two known quinone site inhibitors: Catechins such as epigallocatechin gallate (EGCg) from green tea and modified capsaicin from chili peppers.
Agents that block tNOX interfere with the ability of cancer cells to enlarge to the size required for cell division. Cells that do not reach the size required for division undergo apoptosis or programmed cell death.
World Health Organization statistics note a much lower cancer death rate in countries with a diet high in consumption of chili peppers, especially Mexico and Thailand. Research has shown that a group of compounds referred to as “vanilloids” has important anti-cancer benefits. Capsaicin, the pungent (hot) principle of chili peppers, is one well-studied example of a cancer-fighting vanilloid. In CAPSOL-T®, the pepper source has been selected to maximize cancer-fighting vanilloids other than capsaicin to avoid discomfort due to pungency (hotness) but without loss of anticancer properties.
There have been no adverse effects associated with CAPSOL-T® use. CAPSOL-T® is all-natural and contains only decaffeinated green tea and Capsicum powder, both of which are extremely safe. CAPSOL-T® is well tolerated and appears to be safe to use in conjunction with current cancer drug protocols, radiation treatment or other drugs in general but one should always consult with your physician before doing so.
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